Protein Purification
MilliporeSigma™ Calbiochem™ STING Agonist, 2ʹ3ʹ-cGAMP
A cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 =
MilliporeSigma™ Calbiochem™ Guanosine 3',5'-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt
A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.
MilliporeSigma™ Calbiochem™ InSolution™ H-89, Dihydrochloride
InSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10mm solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48nM).
MilliporeSigma™ Calbiochem™ TNF-α Inhibitor
The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor I, C1
A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) c
MilliporeSigma™ Calbiochem™ Wnt Antagonist III, Box5
The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ PI 3-Kα Inhibitor VIII
The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ mTOR Activator, MHY1485
mTOR Activator, MHY1485, CAS Number: 326914-06-1, is a cell-permeable activator of mTOR that inhibits autophagy by suppressing the fusion between autophagosomes and lysosomes.
MilliporeSigma™ Calbiochem™ PKA Inhibitor 5-24
The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA.
MilliporeSigma™ Calbiochem™ InSolution™ Sirtinol
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity
MilliporeSigma™ Calbiochem™ NF023
A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go
MilliporeSigma™ Calbiochem™ Ginkgolic Acid (15:1)
A cell-permeable anacardic acid analog that inhibits protein SUMO .
MilliporeSigma™ Calbiochem™ Autotaxin Inhibitor III, PF-8380
The Autotaxin Inhibitor III, PF-8380, also referenced under CAS 1144035-53-9, controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ Glycogen Phosphorylase Inhibitor
The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.
MilliporeSigma™ Calbiochem™ Diacylglycerol Kinase Inhibitor II
The Diacylglycerol Kinase Inhibitor II, also referenced under CAS 120166-69-0, controls the biological activity of Diacylglycerol KInase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.